Lung Cell Lines

Ras initiative scientists have devoted significant effort to engineering and characterizing these cell lines so they will be a reliable resource for themselves and the larger ras community.

Lung cell lines.

Name tissue cell type disease oganism age ethnicity genes expressed crl 5844 nci h838 h838 lung. The cells are used as models for the study of lung cancer and the development of drug therapies against it. This is a list of the 60 human cancer cell lines used in the screen and maintained at nci frederick. Atcc also uses crispr cas9 technology to create isogenic cell lines.

H1299 also known as nci h1299 or crl 5803 is a human non small cell lung carcinoma cell line derived from the lymph node which is widely used in research. As with other immortalized cell lines h1299 cells can divide indefinitely. Cell lines in the in vitro screen. By coculturing a kras mutant lung adenocarcinoma cell line with one of three lung stromal cells lines macrophage endothelial or fibroblast and subsequently profiling the secreted proteins the group developed an in vitro model for evaluating the mechanisms by which stromal cells regulate the biologic properties of lung cancer cells.

Browse squamous cell adenocarcinoma sclc and nsclc cell lines for drug response toxicology in vitro models including a549 nci h292 and more. To know about the types of lung cells one must first know about the functioning of the lungs our lungs are vital respiratory organs. Additional lines evaluated for use in the screen and currently available are listed separately at the bottom of the page. Lymph node 3b adenocarcinoma.

Lung cancer cell lines. Select lung cancer cell lines authenticated by ecacc based on associated mutations and diagnosis classifications. Cell lines expressing mutant ras genes are essential tools for finding ways to intervene in ras cancers. Through the removal and culturing of cancerous lung tissue in the explanted tumor of a 58 year old caucasian male.

An x ray is the most common first test for lung problems it can identify air or fluid in the chest fluid in the lung pneumonia masses foreign bodies and. These cells have a homozygous partial deletion of the tp53 gene and as a result do not express the tumor suppressor p53 protein which in part accounts for their. The eml4 alk fusion a549 isogenic cell line is the first cell line derived from the parental non small cell lung cancer cell line a549. These cells are ideal models for cancer as they were derived from tumors isolated from patients or animals.

Non small cell lung cancer homo sapiens 59 yrs caucasian crl 2868 hcc827 lung epithelial adenocarcinoma homo sapiens 39 years adult caucasian.