Mesenchymal Stem Cells Kidney Regeneration

Hickson is part of the research team looking at using stem cells to help regenerate failing kidneys.

Mesenchymal stem cells kidney regeneration.

Several types of stem cells such as bone marrow derived cells adipocyte derived mesenchymal stem cells embryonic stem cells and induced pluripotent stem cells are also applied for renal regeneration. Different types of stem cells ranging from mesenchymal stem cells mscs 1 2 adipose stem cells adscs 3 amniotic fluid stem cells afscs 4 5 renal progenitors rps 6 7 and so forth can stimulate renal repair in vivo in models of acute and chronic kidney failure. Found in the bone marrow these stem cells protect the kidneys from injury and accelerate healing. Mscs can differentiate into a wide range of different cells.

Endogenous or lineage reprogrammed renal progenitor cells represent an attractive possibility for differentiation into multiple renal cell types. Mesenchymal stem cells seem to exert beneficial effects via paracrine effects rather than by direct differentiation into renal parenchymal cells. Our goal is to take a look at how we can repair the diabetic kidney in terms of delaying the rate of progression of kidney failure says latonya hickson m d a mayo clinic nephrologist. There are two types of stem cells treatments that may be utilized in our regenerative protocols for reversing renal failure.

Mesenchymal stem cells are the body s natural defense against kidney damage. Different types of stem cells ranging from mesenchymal stem cells mscs 1 2 adipose stem cells adscs 3 amniotic fluid stem cells afscs 4 5 renal progenitors rps 6 7 and so forth can stimulate renal repair in vivo in models of acute and chronic. In search of innovative and effective strategies to foster the limited regeneration capacity of the kidney several studies have evaluated the ability of mesenchymal stem cells mscs of different origin as an attractive therapeutic tool. Mesenchymal stem cell were selected for this study because the cells have been shown to be immune evasive and can be transplanted without requisite.

Stem cell transplants for renal failure help to replenish the required kidney cells and thus promote a more normal healthy kidney function. Mesenchymal stem cells in the treatment of acute kidney injury. Harvard stem cell institute scientists have identified protein candidates secreted from mesenchymal stem cells that may be administered independently to aid in kidney. Mesenchymal stem cells mscs also known as mesenchymal stromal cells represent adult stem cell lineage of undifferentiated self renewable multipotent cells which originate from the mesoderm germ layer.

The potential to further accelerate the regeneration of wi damaged human renal allografts was evaluated by introducing a mesenchymal stem cell msc treatment during 24 hours of ems perfusion. Although intensive studies have been performed to isolate kidney stem progenitor cells from the mammalian adult kidney whether stem progenitor cells actually exist in the adult kidney is still debated.