Lung Cancer Cell Lines

Browse squamous cell adenocarcinoma sclc and nsclc cell lines for drug response toxicology in vitro models including a549 nci h292 and more.

Lung cancer cell lines.

Standard of care first line treatment for extensive stage small cell lung cancer is platinum chemotherapy carboplatin or cisplatin with etoposide. Lung cancer and normal cell lines atcc no. Non small cell lung cancer. Lung cancer cell lines.

Although human lung tumor derived cell lines play an important role in the investigation of lung cancer biology and genetics there is no comprehensive study comparing the genotypic and phenotypic properties of lung cancer cell lines with those of the individual tumors from which they were derived. The cells are used as models for the study of lung cancer and the development of drug therapies against it. 1 3 despite response rates of 60 to 65. At the time of diagnosis 2 out of 3 people with sclc are already in the extensive stage.

Atcc provides both primary and htert immortalized bronchial epithelial cells and small airway cells that may be used side by side with nsclc or sclc cells as normal controls. Non small cell lung cancer homo sapiens 59 yrs caucasian crl 2868 hcc827 lung epithelial adenocarcinoma homo sapiens. They successfully established over 200 lung cancer cell lines encompassing many. Adi gazdar and john minna pioneered the derivation of lung cancer cell lines during their tenure at the national cancer institute during the 1970s and 1980s and continued to pursue this effort when they moved to ut southwestern in 1991.

We compared a variety of properties of 12 human non small cell lung carcinoma nsclc cell lines. Non small cell lung cancer is an umbrella term for several types of lung cancers. Small cell lung cancer sclc represents about 15 to 20 percent of lung cancers. Doctors believe smoking causes lung cancer by damaging the cells that line the lungs.

All experiments should include physiologically relevant controls. By default data for all cell lines will be retrieved though search results can be restricted by panels or cell lines in the next part of the form. Small cell lung cancer project site navigation project documentation data downloads. Lung cancer cell lines eml4 alk fusion a549 a549.

Select lung cancer cell lines authenticated by ecacc based on associated mutations and diagnosis classifications. A549 cells are adenocarcinomic human alveolar basal epithelial cells and constitute a cell line that was first developed in 1972 by d. Through the removal and culturing of cancerous lung tissue in the explanted tumor of a 58 year old caucasian male. Name tissue cell type disease oganism age ethnicity genes expressed crl 5844 nci h838 h838 lung.